What does massage do? Not only can it promote the regeneration of damaged muscle, but also make it stronger

A team of U.S. researchers has confirmed that mechanical therapy can rapidly remove neutrophils from severely damaged muscle tissue, clearing them of the inflammatory cytokines they release and enhancing the regeneration of muscle fibers.

Massage has been used to treat sore and injured muscle development for more than 3,000 years, but can mechanical exercise therapy really improve the educational results of rehabilitation of damaged muscles? Recently,outcall massage services by the United States Harvard Analysis University Weiss Institute work led by the team in the "Science and Technology Translational Medicine" journal published their own paper that mechanical therapy can quickly carry out the removal of ability to severely injured muscle activity in the tissue of the neutrophils, and remove their release of inflammatory response cell growth factors to promote the regeneration of muscle fibers.

There is a very clear link between mechanical stimulation and immune function.erotic massage hong kong Machine therapy holds the promise of regenerating various tissues, treating damaged muscles, and reducing the use of drugs.

Machine therapy can double the rate of muscle regeneration and reduce tissue scarring. In this new study, to explore how this process works in vivo, they collaborated with soft robotics experts at Harvard University to create a small device that uses sensors and actuators to precisely control parameters such as the magnitude and frequency of the force applied, while observing how damaged tissue responds to ultrasound.

The results showed that after 14 days of repeated force application, the number of damaged muscle fibers was significantly reduced and the cross-sectional area of muscle fibers was significantly increased. In addition, mechanically treated muscles showed better repair and strength recovery than untreated muscles. The more force applied during treatment, the stronger the damaged muscle became, confirming that mechanical therapy improves muscle recovery.

In this regard, the scientists conducted a detailed biological evaluation. They found that after three days of mechanical treatment, there was a significant reduction in febrile cytokines associated with neutrophil activity and a significant reduction in neutrophil infiltration in the muscles, where neutrophils play an important role in the inflammatory process. The researchers hypothesized that the force applied to the muscle may extrude neutrophils and cytokines from the injured tissue.

So what are the problematic effects of neutrophils and related research cells to carry out factors on muscle fibers can regenerate? Scientists cultured muscle progenitor cells (MPCs) in a medium in which neutrophils had been grown, and analysis revealed that the number of MPCs was increasing, but the rate of differentiation and development was decreasing. This suggests that while neutrophil-secreted factors stimulate the growth of muscle cells, their prolonged managed presence results in impairing the production of new muscle fibers. While these inflammatory responses are important for regeneration during the initial design phase of healing, the rapid and timely elimination of inflammation to complete the regenerative treatment process is of equal importance.

The researchers then analyzed muscle fiber types in model mice with limb injuries before and after treatment. The results showed that type IIX muscle fibers were found more often in healthy and mechanically treated muscles, while fewer type IIX muscle fibers and more type IIA muscle fibers were found in untreated and injured muscles. This difference explains the increase in muscle fiber size and the greater force produced by IIX fibers than IIA fibers after treatment.

As a next step, the team plans to validate the effects of mechanotherapy in larger animals and then test its efficacy in humans.